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Most foreign authors consider only anaerobic radiant fungi to be the true causative agent of Actinomycosis, while domestic scientists, based on the works of S. F. Dmitriev, recognize both aerobic and anaerobic radiant fungi as causative agents of actinomycosis (see Actinomycetes). Accounting for Actinomycosis in the USSR and abroad is not mandatory. Cases of Actinomycosis have been reported in almost all countries of the world. Data on the number of patients with actinomycosis in a given country are given in the literature based on the summation of Clomiphene descriptions of individual observations. GO Suteev (1951) explained the growth of actinomycosis by improving the diagnosis of the disease.
The exogenous theory of infection has lost its dominant significance by now. According to the endogenous theory, the causative agents of actinomycosis in humans are, as a rule, radiant fungi that constantly saprophyte in the body (oral cavity, gastrointestinal tract, upper respiratory tract, etc.).
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The occurrence of the disease is facilitated by a decrease in the body's resistance due to the disease (flu, tuberculosis, diabetes, etc.), hypothermia, pregnancy, and so on. The protective function of Clomiphene membrane is disturbed by the previous local inflammatory process or trauma that violates its integrity, including as a result of surgery.
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In the pathogenesis of actinomycosis, salivary, bile, urinary, fecal calculi play a peculiar role: they are both a traumatic factor and carriers of radiant fungi. Confirmation of the endogenous theory of infection with actinomycosis is the development of the disease at the site of a closed injury.
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An example of the exogenous genesis of Actinomycosis is the development of a disease in the area of an open injury, a skin disease (for example, eczema). The development of actinomycosis in the urachus, epithelial coccygeal passage, branchial fistulas with subsequent spread to the surrounding tissues can be of both endo- and exogenous origin.
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A certain value in the pathogenesis of clomid has a nonspecific microflora; the frequency of its allocation is directly proportional to the prescription of actinomycosis. In the presence of concomitant nonspecific microflora, actinomycosis is more severe, with frequent exacerbations, has a pronounced tendency to spread and requires longer treatment.
Learn MoreThe severity of fibrosis is different and depends on the reaction of the body.
The study of actinomycosis in the experiment is associated with the difficulty of creating a model of the disease, since actinomycosis in laboratory animals tends to self-heal.
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The macroscopic picture of Actinomycosis is characterized by the formation of granulomas, their decay, suppuration, and in parallel with this, fibrosis of festering granulomas with the formation of scar, cartilage-like tissue.
The latter is permeated with small multiple abscesses, which gives the tissues a spongy appearance resembling honeycombs. A proliferative reaction develops around the radiant fungus that has penetrated the tissue and a granuloma occurs, delimiting the infectious focus from the surrounding tissues.
With the help of microscopy, it is found that the cellular composition of the granuloma changes as the process develops.
While necrosis and cell breakdown occurs in the central part of the nodule, the formation of clomid structures is observed in the surrounding granulation tissue. Typical for actinomycotic granuloma is the presence of xanthoma cells and the process of fibrosis. Although the relationship of Clomiphene cells with colonies of the fungus has not been completely elucidated, there is a certain pattern: with a large accumulation of drusen of the fungus, there are few xanthomous cells, in the absence of them, there are many.
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Druses of actinomycetes are most often observed in the central parts of granulomas and are surrounded by a zone of leukocyte infiltration. When the fungus dies, this zone appears to be more rarefied. Around the leukocytes, surrounded in turn by epithelioid cells, giant cells of foreign bodies can often be observed.
the second variant (second stage) is characterized by a variegated composition of granulation tissue, in which, in addition to the above, there are epithelioid, lymphoid, plasma, xanthoma cells, hyaline balls, collagen fibers, and the presence of hyalinized scars and various sizes of abscesses. In the diagnosis of A., along with the study of tissue reactions, the detection of drusen of actinomycetes is also of great importance (Fig. 2).